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KMID : 0381120140360050559
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Genes and Genomics
2014 Volume.36 No. 5 p.559 ~ p.564
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KIF1B polymorphisms associated with the risk of inflammatory demyelinating disease in Korean population
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Lee Jin-Sol
Bae Joon-Seol
Park Byung-Lae
Cheong Hyun-Sub
Kim Jeong-Hyun
Kim Jason Yong-Ha
Kim Ho-Jin
Shin Hyoung-Doo
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Abstract
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In the present study, we explored the possible association between KIF1B polymorphisms and inflammatory demyelinating disease (IDD) susceptibility. Eleven single nucleotide polymorphisms (SNPs) were selected for the present study based on the literature, as well as linkage disequilibrium, minor allele frequency, and location. The SNPs were genotyped in 178 IDD subjects consisting of 99 neuromyelitis optica subjects, 79 multiple sclerosis subjects, and 237 healthy controls (Total N = 415). We next preformed logistic analysis to validate associations between the KIF1B polymorphisms and the risk of IDD. Statistical analyses revealed that rs17396382 and ht4 were significantly associated with IDD susceptibility with odds ratios of 2.22 and 2.17 (P = 0.001 and 0.004; P corr = 0.01 and 0.03, respectively). In addition, although P values for six variants (rs3748576, rs7520935, rs2275424, rs11576866, rs17411502, and rs11121552) and one haplotype (ht1) did not reach the threshold of significance after correction for multiple testing, the SNPs showed a nominal association in primary analysis (P = 0.02 ~ 0.04). Our results suggest that rs17396382 and ht4 might be involved in IDD pathogenesis.
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KEYWORD
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KIF1B, Single nucleotide polymorphism (SNP), Haplotype, Inflammatory demyelinating disease (IDD)
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